Resveratrol protects against ICV collagenase-induced neurobehavioral and biochemical deficits
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چکیده
منابع مشابه
Resveratrol protects Neuro-2a cells against Thapsigrin-induced damage
Alteration of the calcium homeostasis of endoplasmic reticulum (ER) results in excessive calcium accumulation in cytoplasm, which is one the main causes of neuronal cell death in neurodegenerative disorders. Thapsigargin (TG) is a drug that widely used to induce ER stress by specific inhibition of the ER Ca2+-ATPase. In this study, we investigated the neuroprotective potential of resveratrol, a...
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The excessive consumption of high cholesterol diet has been associated with an increased incidence oflipidaemia. Lipidaemia is enhanced by formation of oxidative stress, lipid peroxidation and hyperglycaemia. The aim ofthese experiments was to investigate the protective effect of resveratrol co-administered with cholesterol diet inducedhyperlipidaemia in rabbits. Thirty rabbits divided into six...
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Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration...
متن کاملResveratrol protects against methotrexate-induced hepatic injury in rats.
PURPOSE The aim of this study to investigate the possible protective effect of resveratrol on some liver and serum/plasma parameters in methotrexate induced toxicity in rats. Methotrexate is used widely to treat various neoplastic diseases such as acute lymphoblastic leukemia, lymphoma, solid cancers, and autoimmune diseases. We hypothesized that resveratrol has a potential to decrease the oxid...
متن کاملResveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice
Objective(s):Resveratrol (RES) is a polyphenol compound that has been shown a promising cardioprotective effect. However, some reports have yielded conflicting findings. Herein, we investigated the anti-atherosclerotic effects of RES in apolipoprotein E (apo E)-deficient mice on a high cholesterol diet. Materials and Methods: Firstly, atherosclerosis was induced by feeding a high cholesterol di...
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ژورنال
عنوان ژورنال: Journal of Inflammation
سال: 2017
ISSN: 1476-9255
DOI: 10.1186/s12950-017-0158-3